How do triptans relieve migraines? Unlike other acute medications, triptans are considered selective serotonin receptor agonists, meaning that triptans work by stimulating serotonin, a neurotransmitter found in the brain, to reduce inflammation and constrict blood vessels, thereby stopping the headache or migraine. Can you overdose on zolmitriptan? There is no experience with acute overdose of ZOMIG. The elimination half-life of ZOMIG is 3 hours [see CLINICAL PHARMACOLOGY]; therefore, monitor patients after overdose with ZOMIG for at least 15 hours or until symptoms or signs resolve.
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